Delivery of antagomiR204-conjugated gold nanoparticles from PLGA sheets and its implication in promoting osseointegration of titanium implant in type 2 diabetes mellitus
Identifieur interne : 000291 ( Main/Exploration ); précédent : 000290; suivant : 000292Delivery of antagomiR204-conjugated gold nanoparticles from PLGA sheets and its implication in promoting osseointegration of titanium implant in type 2 diabetes mellitus
Auteurs : Xiangwei Liu ; Naiwen Tan ; Yuchao Zhou ; Hongbo Wei ; Shuai Ren ; Fan Yu ; Hui Chen ; Chengming Jia ; Guodong Yang [République populaire de Chine] ; Yingliang SongSource :
- International Journal of Nanomedicine [ 1176-9114 ] ; 2017.
Abstract
Impaired osseointegration of the implant remains the big hurdle for dental implant therapy in diabetic patients. In this study, the authors first identified that miR204 was strikingly highly expressed in the bone mesenchymal stem cells (BMSCs) of diabetic rats. Forced expression of miR204 repressed the osteogenic potential of BMSCs, while inhibition of miR204 significantly increased the osteogenic capacity. Moreover, the miR204 inhibitor was conjugated with gold nanoparticles (AuNP-antagomiR204) and dispersed them in the poly(lactic-co-glycolic acid) (PLGA) solution. The AuNP-antagomiR204 containing PLGA solution was applied for coating the surface of titanium implant. Electron microscope revealed that an ultrathin sheet was formed on the surface of the implant, and the AuNPs were evenly dispersed in the coated PLGA sheet. Cellular experiments revealed that these encapsulated AuNP-antagomiR204 were able to be released from the PLGA sheet and uptaken by adherent BMSCs. In vivo animal study further confirmed that the AuNP-antagomiR204 released from PLGA sheet promoted osseointegration, as revealed by microcomputerized tomography (microCT) reconstruction and histological assay. Taken together, this study established that miR204 misexpression accounted for the deficient osseointegation in diabetes mellitus, while PLGA sheets aided the release of AuNP-antagomiR204, which would be a promising strategy for titanium implant surface functionalization toward better osseointegration.
Url:
DOI: 10.2147/IJN.S124584
PubMed: 29026303
PubMed Central: 5627761
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Delivery of antagomiR204-conjugated gold nanoparticles from PLGA sheets and its implication in promoting osseointegration of titanium implant in type 2 diabetes mellitus</title><author><name sortKey="Liu, Xiangwei" sort="Liu, Xiangwei" uniqKey="Liu X" first="Xiangwei" last="Liu">Xiangwei Liu</name><affiliation><nlm:aff id="af1-ijn-12-7089">State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Implant Dentistry</nlm:aff><wicri:noCountry code="subfield">Department of Implant Dentistry</wicri:noCountry></affiliation></author><author><name sortKey="Tan, Naiwen" sort="Tan, Naiwen" uniqKey="Tan N" first="Naiwen" last="Tan">Naiwen Tan</name><affiliation><nlm:aff id="af1-ijn-12-7089">State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Implant Dentistry</nlm:aff><wicri:noCountry code="subfield">Department of Implant Dentistry</wicri:noCountry></affiliation></author><author><name sortKey="Zhou, Yuchao" sort="Zhou, Yuchao" uniqKey="Zhou Y" first="Yuchao" last="Zhou">Yuchao Zhou</name><affiliation><nlm:aff id="af1-ijn-12-7089">State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Implant Dentistry</nlm:aff><wicri:noCountry code="subfield">Department of Implant Dentistry</wicri:noCountry></affiliation></author><author><name sortKey="Wei, Hongbo" sort="Wei, Hongbo" uniqKey="Wei H" first="Hongbo" last="Wei">Hongbo Wei</name><affiliation><nlm:aff id="af1-ijn-12-7089">State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Implant Dentistry</nlm:aff><wicri:noCountry code="subfield">Department of Implant Dentistry</wicri:noCountry></affiliation></author><author><name sortKey="Ren, Shuai" sort="Ren, Shuai" uniqKey="Ren S" first="Shuai" last="Ren">Shuai Ren</name><affiliation><nlm:aff id="af1-ijn-12-7089">State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Implant Dentistry</nlm:aff><wicri:noCountry code="subfield">Department of Implant Dentistry</wicri:noCountry></affiliation></author><author><name sortKey="Yu, Fan" sort="Yu, Fan" uniqKey="Yu F" first="Fan" last="Yu">Fan Yu</name><affiliation><nlm:aff id="af2-ijn-12-7089">Department of Prosthodontics, School of Stomatology</nlm:aff><wicri:noCountry code="subfield">School of Stomatology</wicri:noCountry></affiliation></author><author><name sortKey="Chen, Hui" sort="Chen, Hui" uniqKey="Chen H" first="Hui" last="Chen">Hui Chen</name><affiliation><nlm:aff id="af3-ijn-12-7089">Department of Plastic Surgery, Tangdu Hospital</nlm:aff><wicri:noCountry code="subfield">Tangdu Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Jia, Chengming" sort="Jia, Chengming" uniqKey="Jia C" first="Chengming" last="Jia">Chengming Jia</name><affiliation><nlm:aff id="af4-ijn-12-7089">Department of Traditional Chinese Medicine, Xijing Hospital</nlm:aff><wicri:noCountry code="subfield">Xijing Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Yang, Guodong" sort="Yang, Guodong" uniqKey="Yang G" first="Guodong" last="Yang">Guodong Yang</name><affiliation wicri:level="1"><nlm:aff id="af5-ijn-12-7089">Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi’an, China</nlm:aff><country xml:lang="fr">République 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type="doi">10.2147/IJN.S124584</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">002E48</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E48</idno><idno type="wicri:Area/Pmc/Curation">002E48</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002E48</idno><idno type="wicri:Area/Pmc/Checkpoint">000267</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000267</idno><idno type="wicri:Area/Ncbi/Merge">007235</idno><idno type="wicri:Area/Ncbi/Curation">007235</idno><idno type="wicri:Area/Ncbi/Checkpoint">007235</idno><idno type="wicri:doubleKey">1176-9114:2017:Liu X:delivery:of:antagomir</idno><idno type="wicri:Area/Main/Merge">000291</idno><idno type="wicri:Area/Main/Curation">000291</idno><idno type="wicri:Area/Main/Exploration">000291</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Delivery of antagomiR204-conjugated gold nanoparticles from PLGA sheets and its implication in promoting osseointegration of titanium implant in type 2 diabetes mellitus</title><author><name sortKey="Liu, Xiangwei" sort="Liu, Xiangwei" uniqKey="Liu X" first="Xiangwei" last="Liu">Xiangwei Liu</name><affiliation><nlm:aff id="af1-ijn-12-7089">State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Implant Dentistry</nlm:aff><wicri:noCountry code="subfield">Department of Implant Dentistry</wicri:noCountry></affiliation></author><author><name sortKey="Tan, Naiwen" sort="Tan, Naiwen" uniqKey="Tan N" first="Naiwen" last="Tan">Naiwen Tan</name><affiliation><nlm:aff id="af1-ijn-12-7089">State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Implant Dentistry</nlm:aff><wicri:noCountry code="subfield">Department of Implant Dentistry</wicri:noCountry></affiliation></author><author><name sortKey="Zhou, Yuchao" sort="Zhou, Yuchao" uniqKey="Zhou Y" first="Yuchao" last="Zhou">Yuchao Zhou</name><affiliation><nlm:aff id="af1-ijn-12-7089">State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Implant Dentistry</nlm:aff><wicri:noCountry code="subfield">Department of Implant Dentistry</wicri:noCountry></affiliation></author><author><name sortKey="Wei, Hongbo" sort="Wei, Hongbo" uniqKey="Wei H" first="Hongbo" last="Wei">Hongbo Wei</name><affiliation><nlm:aff id="af1-ijn-12-7089">State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Implant Dentistry</nlm:aff><wicri:noCountry code="subfield">Department of Implant Dentistry</wicri:noCountry></affiliation></author><author><name sortKey="Ren, Shuai" sort="Ren, Shuai" uniqKey="Ren S" first="Shuai" last="Ren">Shuai Ren</name><affiliation><nlm:aff id="af1-ijn-12-7089">State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Implant Dentistry</nlm:aff><wicri:noCountry code="subfield">Department of Implant Dentistry</wicri:noCountry></affiliation></author><author><name sortKey="Yu, Fan" sort="Yu, Fan" uniqKey="Yu F" first="Fan" last="Yu">Fan Yu</name><affiliation><nlm:aff id="af2-ijn-12-7089">Department of Prosthodontics, School of Stomatology</nlm:aff><wicri:noCountry code="subfield">School of Stomatology</wicri:noCountry></affiliation></author><author><name sortKey="Chen, Hui" sort="Chen, Hui" uniqKey="Chen H" first="Hui" last="Chen">Hui Chen</name><affiliation><nlm:aff id="af3-ijn-12-7089">Department of Plastic Surgery, Tangdu Hospital</nlm:aff><wicri:noCountry code="subfield">Tangdu Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Jia, Chengming" sort="Jia, Chengming" uniqKey="Jia C" first="Chengming" last="Jia">Chengming Jia</name><affiliation><nlm:aff id="af4-ijn-12-7089">Department of Traditional Chinese Medicine, Xijing Hospital</nlm:aff><wicri:noCountry code="subfield">Xijing Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Yang, Guodong" sort="Yang, Guodong" uniqKey="Yang G" first="Guodong" last="Yang">Guodong Yang</name><affiliation wicri:level="1"><nlm:aff id="af5-ijn-12-7089">Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi’an, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi’an</wicri:regionArea><wicri:noRegion>Xi’an</wicri:noRegion></affiliation></author><author><name sortKey="Song, Yingliang" sort="Song, Yingliang" uniqKey="Song Y" first="Yingliang" last="Song">Yingliang Song</name><affiliation><nlm:aff id="af1-ijn-12-7089">State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Implant Dentistry</nlm:aff><wicri:noCountry code="subfield">Department of Implant Dentistry</wicri:noCountry></affiliation></author></analytic><series><title level="j">International Journal of Nanomedicine</title><idno type="ISSN">1176-9114</idno><idno type="eISSN">1178-2013</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Impaired osseointegration of the implant remains the big hurdle for dental implant therapy in diabetic patients. In this study, the authors first identified that miR204 was strikingly highly expressed in the bone mesenchymal stem cells (BMSCs) of diabetic rats. Forced expression of miR204 repressed the osteogenic potential of BMSCs, while inhibition of miR204 significantly increased the osteogenic capacity. Moreover, the miR204 inhibitor was conjugated with gold nanoparticles (AuNP-antagomiR204) and dispersed them in the poly(lactic-co-glycolic acid) (PLGA) solution. The AuNP-antagomiR204 containing PLGA solution was applied for coating the surface of titanium implant. Electron microscope revealed that an ultrathin sheet was formed on the surface of the implant, and the AuNPs were evenly dispersed in the coated PLGA sheet. Cellular experiments revealed that these encapsulated AuNP-antagomiR204 were able to be released from the PLGA sheet and uptaken by adherent BMSCs. In vivo animal study further confirmed that the AuNP-antagomiR204 released from PLGA sheet promoted osseointegration, as revealed by microcomputerized tomography (microCT) reconstruction and histological assay. Taken together, this study established that miR204 misexpression accounted for the deficient osseointegation in diabetes mellitus, while PLGA sheets aided the release of AuNP-antagomiR204, which would be a promising strategy for titanium implant surface functionalization toward better osseointegration.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Van Velzen, Fjj" uniqKey="Van Velzen F">FJJ van Velzen</name></author><author><name sortKey="Ofec, R" uniqKey="Ofec R">R Ofec</name></author><author><name sortKey="Schulten, Eajm" uniqKey="Schulten E">EAJM Schulten</name></author><author><name sortKey="Ten Bruggenkate, Cm" uniqKey="Ten Bruggenkate C">CM ten Bruggenkate</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Charyeva, O" uniqKey="Charyeva O">O Charyeva</name></author><author><name sortKey="Altynbekov, K" uniqKey="Altynbekov K">K Altynbekov</name></author><author><name sortKey="Zhartybaev, R" 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Ochiya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, K" uniqKey="Wu K">K Wu</name></author><author><name sortKey="Song, W" uniqKey="Song W">W Song</name></author><author><name sortKey="Zhao, L" uniqKey="Zhao L">L Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name></author><author><name sortKey="Wu, G" uniqKey="Wu G">G Wu</name></author><author><name sortKey="Feng, Z" uniqKey="Feng Z">Z Feng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author><author><name sortKey="Agarwal, P" uniqKey="Agarwal P">P Agarwal</name></author><author><name sortKey="Zhao, S" uniqKey="Zhao S">S Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, Y" uniqKey="Xu Y">Y Xu</name></author><author><name sortKey="Kim, Cs" uniqKey="Kim C">CS Kim</name></author><author><name sortKey="Saylor, Dm" uniqKey="Saylor D">DM Saylor</name></author><author><name sortKey="Koo, D" uniqKey="Koo D">D Koo</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Chen, Hui" sort="Chen, Hui" uniqKey="Chen H" first="Hui" last="Chen">Hui Chen</name><name sortKey="Jia, Chengming" sort="Jia, Chengming" uniqKey="Jia C" first="Chengming" last="Jia">Chengming Jia</name><name sortKey="Liu, Xiangwei" sort="Liu, Xiangwei" uniqKey="Liu X" first="Xiangwei" last="Liu">Xiangwei Liu</name><name sortKey="Ren, Shuai" sort="Ren, Shuai" uniqKey="Ren S" first="Shuai" last="Ren">Shuai Ren</name><name sortKey="Song, Yingliang" sort="Song, Yingliang" uniqKey="Song Y" first="Yingliang" last="Song">Yingliang Song</name><name sortKey="Tan, Naiwen" sort="Tan, Naiwen" uniqKey="Tan N" first="Naiwen" last="Tan">Naiwen Tan</name><name sortKey="Wei, Hongbo" sort="Wei, Hongbo" uniqKey="Wei H" first="Hongbo" last="Wei">Hongbo Wei</name><name sortKey="Yu, Fan" sort="Yu, Fan" uniqKey="Yu F" first="Fan" last="Yu">Fan Yu</name><name sortKey="Zhou, Yuchao" sort="Zhou, Yuchao" uniqKey="Zhou Y" first="Yuchao" last="Zhou">Yuchao Zhou</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Yang, Guodong" sort="Yang, Guodong" uniqKey="Yang G" first="Guodong" last="Yang">Guodong Yang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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